Lymphoma Clinical Trials

1,320 recruiting

Understanding Lymphoma Clinical Trials

Rituximab (Rituxan), first approved in 1997 after pivotal clinical trials, fundamentally changed the treatment of B-cell lymphomas and remains a cornerstone of therapy decades later. Since then, clinical trials have delivered additional breakthroughs including brentuximab vedotin for Hodgkin lymphoma, polatuzumab vedotin for diffuse large B-cell lymphoma, and CAR-T cell therapies like axicabtagene ciloleucel (Yescarta) for patients with relapsed aggressive lymphoma. With over 70 subtypes of lymphoma, clinical trials are essential for developing treatments tailored to specific disease biology, and many patients with lymphoma have access to promising new therapies only through trial participation.

Why Consider a Clinical Trial?

Lymphoma is not a single disease — it includes Hodgkin lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, and many other subtypes, each with distinct behavior and treatment needs. While some lymphomas respond well to standard chemoimmunotherapy, others are harder to treat, and patients whose lymphoma returns after initial treatment face limited options. Clinical trials can provide access to next-generation antibodies, antibody-drug conjugates, bispecific antibodies, and cellular therapies that may be more effective or less toxic than existing treatments. Participation in a lymphoma trial also means your care is guided by a detailed protocol developed by leading experts and reviewed by multiple regulatory bodies. You receive close monitoring, including frequent imaging and blood work, that can detect changes in your disease earlier than routine follow-up schedules. For patients with indolent (slow-growing) lymphomas who are on a watch-and-wait approach, there are trials studying whether early intervention with novel agents can delay or prevent the need for chemotherapy altogether.

Frequently Asked Questions

Common questions about Lymphoma clinical trials

Yes. Hodgkin lymphoma and non-Hodgkin lymphoma are biologically distinct diseases with different treatment approaches, so they have separate clinical trials. Non-Hodgkin lymphoma trials are further divided by subtype, such as diffuse large B-cell lymphoma or follicular lymphoma. Your specific subtype determines which trials you are eligible for.

Yes. Some trials focus specifically on patients in remission, studying maintenance therapies or monitoring strategies designed to prevent relapse. There are also survivorship trials that address long-term side effects of treatment. Ask your oncologist about trials that match your current disease status.

It is extremely rare for a lymphoma trial to have a placebo-only group. Most trials compare the new treatment plus standard therapy against standard therapy alone, or compare two active treatments. You will always know before enrolling whether the trial includes a placebo component.

Many trials require a fresh biopsy, especially if your most recent one is older than a few months or if you have received treatment since your last biopsy. This is because lymphoma biology can change over time or after treatment. The biopsy helps confirm your subtype and test for biomarkers that determine trial eligibility.

Many academic cancer centers offer virtual pre-screening consultations to determine if you might qualify before you travel. Some trials allow portions of treatment and monitoring to be done at a local oncologist through satellite site arrangements. Ask the trial coordinator about remote participation options and travel reimbursement programs.

Showing 120 of 1,320 trials

Recruiting
Phase 2

Testing the Effectiveness of the Anti-cancer Drug, Mirdametinib, in Treating Relapsed, Refractory Chronic Lymphocytic Leukemia

Recurrent Chronic Lymphocytic LeukemiaRecurrent Small Lymphocytic LymphomaRefractory Chronic Lymphocytic Leukemia+1 more
National Cancer Institute (NCI)20 enrolled1 locationNCT07061951
Recruiting
Phase 1

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination With CC-220 and/or CC-99282 in Participants With B-Cell Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma
Hoffmann-La Roche121 enrolled26 locationsNCT05169515
Recruiting
Phase 3

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Classic Follicular LymphomaFollicular Lymphoma With Unusual Cytological Features
National Cancer Institute (NCI)600 enrolled260 locationsNCT06337318
Recruiting
Phase 1

A Study to Evaluate MK-1045 (CN201) in Participants With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (MK-1045-001/CN201-101)

Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
MSD R&D (China) Co., Ltd.100 enrolled15 locationsNCT06189391
Recruiting
Phase 1

Testing the Combination of Nivolumab and ASTX727 for Relapsed or Refractory B-Cell Lymphoma

Recurrent B-Cell Non-Hodgkin LymphomaRefractory B-Cell Non-Hodgkin LymphomaRecurrent Diffuse Large B-Cell Lymphoma+3 more
National Cancer Institute (NCI)32 enrolled9 locationsNCT05272384
Recruiting
Phase 2

Comparing the Effectiveness of the Immunotherapy Agents Rituximab or Mosunetuzumab in Patients With Nodular Lymphocyte-Predominant Hodgkin Lymphoma, NORM Trial

Nodular Lymphocyte Predominant B-Cell LymphomaRecurrent Nodular Lymphocyte Predominant B-Cell LymphomaRefractory Nodular Lymphocyte Predominant B-Cell Lymphoma
National Cancer Institute (NCI)70 enrolled35 locationsNCT05886036
Recruiting
Phase 1

Testing the Addition of Lenalidomide and Nivolumab to the Usual Treatment for Primary CNS Lymphoma

Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System
National Cancer Institute (NCI)47 enrolled54 locationsNCT04609046
Recruiting
Phase 1Phase 2

Testing the Safety of Anti-Cancer Drug, CX-5461 (Pidnarulex), in Treating Lymphoma With Specific Changes in the MYC Gene

Burkitt LymphomaHigh Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 RearrangementsDouble-Expressor Lymphoma
National Cancer Institute (NCI)50 enrolled1 locationNCT07069699
Recruiting
Phase 3

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
National Cancer Institute (NCI)1,875 enrolled399 locationsNCT05675410
Recruiting
Phase 2

Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma

Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 RearrangementsRefractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 RearrangementsRecurrent Diffuse Large B-Cell Lymphoma+12 more
National Cancer Institute (NCI)120 enrolled69 locationsNCT06649812
Recruiting
Phase 3

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
National Cancer Institute (NCI)247 enrolled627 locationsNCT04269902
Recruiting
Phase 2

Testing the Anti-cancer Drug, Glofitamab, in Patients With Mantle Cell Lymphoma (A Type of Blood Cancer) Whose Disease Returned After CAR-T Cell Therapy

Recurrent Mantle Cell LymphomaRefractory Mantle Cell Lymphoma
National Cancer Institute (NCI)20 enrolled1 locationNCT07003295
Recruiting
Phase 2

Testing the Combination of Venetoclax and Rituximab, in Comparison to the Usual Treatment (Ibrutinib Plus Rituximab or Zanubrutinib Alone) for Waldenstrom's Macroglobulinemia/Lymphoplasmacytic Lymphoma

Waldenstrom MacroglobulinemiaLymphoplasmacytic Lymphoma
National Cancer Institute (NCI)92 enrolled125 locationsNCT04840602
Recruiting
Phase 3

A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
BeOne Medicines630 enrolled155 locationsNCT06943872
Recruiting
Phase 3

A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients

Untreated Follicular Lymphoma
AstraZeneca1,018 enrolled135 locationsNCT06549595
Recruiting
Phase 2

TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Advanced Solid TumorsMultiple MyelomaLymphoma, Non-Hodgkin
American Society of Clinical Oncology4,200 enrolled166 locationsNCT02693535
Recruiting
Phase 1

U69-CART-Cells For R/R T-ALL

Relapsed/Refractory T-lymphoblastic Leukemia/Lymphoma
The First Affiliated Hospital of Soochow University12 enrolled1 locationNCT07350863
Recruiting
Phase 2

Daratumumab for Relapsed/Refractory Primary Effusion Lymphoma, Plasmablastic Lymphoma, and Multicentric Castleman Disease

Lymphoma, Primary Effusion
National Cancer Institute (NCI)28 enrolled1 locationNCT05907759
Recruiting
Phase 1Phase 2

A Study to Investigate Safety and Effectiveness of BGB-16673 in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

Refractory CancerB-cell LymphomaB-cell Malignancy+1 more
BeOne Medicines80 enrolled49 locationsNCT06634589
Recruiting
Phase 2Phase 3

Brentuximab Vedotin for Newly Diagnosed cHL in Chinese CAYA Based on PET/CT Assessment

TreatmentSurvivalClassical Hodgkin Lymphoma+6 more
Children's Cancer Group, China96 enrolled1 locationNCT06563245