Phase 2 Advanced Breast Cancer Clinical Trials
28 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 28 trials
Recruiting
Phase 2
A Study of Disitamab Vedotin With Other Anticancer Drugs in Solid Tumors
Metastatic Breast CancerBreast NeoplasmsGastroesophageal Junction Adenocarcinoma+7 more
Seagen, a wholly owned subsidiary of Pfizer172 enrolled139 locationsNCT06157892
Recruiting
Phase 2
Platform Study of ADC Rechallenge in ADC-treated Metastatic Breast Cancer
Metastatic Breast CancerAdvanced Breast Cancer
Fudan University160 enrolled1 locationNCT06649331
Recruiting
Phase 1Phase 2
Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors
Advanced Breast CancerAdvanced Solid Tumors
Ensem Therapeutics233 enrolled10 locationsNCT06993844
Recruiting
Phase 1Phase 2
Trial of 225Ac-DOTATATE (RYZ101) in Subjects With ER+, HER2-negative Unresectable or Metastatic Breast Cancer Expressing SSTRs.
Metastatic Breast CancerHER2-negative Breast CancerAdvanced Breast Cancer+1 more
RayzeBio, Inc.124 enrolled31 locationsNCT06590857
Recruiting
Phase 2
Safety and Efficacy of T-DXd vs. CDK4/6i-based ET as First-line Therapy of HR-positive and HER2-low/Ultralow Advanced Breast Cancer Patients Classified as Non-luminal Subtype
Advanced Breast CancerAdvanced Breast Carcinoma
MedSIR200 enrolled47 locationsNCT06486883
Recruiting
Phase 2
Genetically-informed Therapy for ER+ Breast Cancer Post-CDK4/6 Inhibitor
Advanced Breast Cancer
Dartmouth-Hitchcock Medical Center135 enrolled1 locationNCT05933395
Recruiting
Phase 2
Efficacy and Safety of Trastuzumab Rezetecan Followed by CDK4/6 Inhibitors and Endocrine Therapy in HR+/HER2-Low/Ultra-Low Advanced Breast Cancer
Advanced Breast Cancer
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University45 enrolled1 locationNCT07037199
Recruiting
Phase 2
Sequencing Antibody Drug Conjugates in ER+/HER2 LOW/ULTRA LOW MBC
Breast CancerMetastatic Breast CancerAdvanced Breast Cancer
Reshma L. Mahtani, D.O.75 enrolled3 locationsNCT06263543
Recruiting
Phase 2
Patritumab Deruxtecan (U3-1402) in Unresectable Locally Advanced or Metastatic Breast Cancer
Metastatic Breast CancerAdvanced Breast Cancer
Gustave Roussy, Cancer Campus, Grand Paris139 enrolled11 locationsNCT04965766
Recruiting
Phase 2
Optimal Methods to Characterize ADC Resistance in Solid Tumors and Identify Clinically Useful Biomarkers
Advanced Breast CancerAdvanced Gastric CancerAdvanced Urothelial Cancer+1 more
UNICANCER400 enrolled1 locationNCT07259226
Recruiting
Phase 2
Eribulin With or Without Trastuzumab-biosimilar in Patients With HER2-overexpressed Recurrent or Stage IV Breast Cancer
Advanced Breast Cancer
Seoul National University Hospital180 enrolled1 locationNCT05530057
Recruiting
Phase 2
Continuous or Intermittent Pyrotinib for HER2-positive Advanced Breast Cancer
Advanced Breast Cancer
Wenjin Yin186 enrolled1 locationNCT07180082
Recruiting
Phase 2
A Study of MHB036C Combined With MHB039A in Patients With Advanced Breast Cancer or Other Advanced Malignant Solid Tumors
Advanced Breast CancerAdvanced Malignant Solid Tumor
Minghui Pharmaceutical (Hangzhou) Ltd210 enrolled1 locationNCT07130383
Recruiting
Phase 2
Iparomlimab and Tuvonralimab (QL1706) in Patients With HR-positive, HER2-negative Advanced Breast Cancer
Advanced Breast Cancer
Wenjin Yin123 enrolled1 locationNCT07180160
Recruiting
Phase 2
Evaluating the Efficacy and Safety of Fulvestrant Plus DNA Damage Repair Inhibitors After a CDK4/6 Inhibitor
Advanced Breast Cancer
Seoul National University Hospital64 enrolled1 locationNCT05536128
Recruiting
Phase 2
Talazoparib in Advanced Breast Cancer Patients With Homologous Recombinant Deficiency
Advanced Breast Cancer
Seoul National University Hospital70 enrolled1 locationNCT04892693
Recruiting
Phase 2
FUnctional Selection of Advanced Breast Cancer Patients for Talazoparib Treatment Using the REpair Capacity (RECAP) Test
Advanced Breast Cancer
Erasmus Medical Center66 enrolled3 locationsNCT06193525
Recruiting
Phase 2
Organoid-based Functional Precision Therapy for Advanced Breast Cancer
HER2-negative Breast CancerAdvanced Breast Cancer
Guangdong Provincial People's Hospital252 enrolled1 locationNCT06102824
Recruiting
Phase 2
Efficacy and Safety of Ribociclib Combined With AI Versus Physician&Amp;#39;s Choice of Chemotherapy Sequential Endocrine Therapy in ER Middle-low-expression/HER2-negative Advanced Breast Cancer (Rachel)
Advanced Breast Cancer
The First Affiliated Hospital with Nanjing Medical University190 enrolled1 locationNCT06656624
Recruiting
Phase 2
SNF Platform Study of HR+/ HER2-advanced Breast Cancer
Breast CancerBreast NeoplasmHER2-negative Breast Cancer+2 more
Fudan University620 enrolled1 locationNCT05594095