Asthma Clinical Trials

Not necessarily. While many biologic trials focus on severe asthma, there are also trials for moderate asthma, exercise-induced asthma, and newly diagnosed asthma. Some trials study prevention strategies in children at high risk of developing asthma. The eligibility criteria vary widely by study.

Most asthma trials do not require you to stop your controller medications (inhaled corticosteroids and long-acting bronchodilators). However, some trials may include a steroid reduction phase where your inhaled steroid dose is gradually lowered to see if the study drug maintains control independently. You will always have access to your rescue inhaler.

Trials have safety protocols specifically designed for patients with frequent exacerbations. These include regular lung function monitoring, 24-hour contact with the study team, and clear guidelines for when to seek emergency care. If your asthma worsens significantly, the trial protocol will have a predefined plan, which may include rescue medication or withdrawal from the study.

Most asthma trials require spirometry, a breathing test that measures how much air you can exhale and how quickly. You will typically need to demonstrate reversibility — meaning your lung function improves after using a bronchodilator. Some trials also require FeNO testing, methacholine challenge tests, or peak flow monitoring at home.

Yes. Pediatric asthma trials are available, and they include additional safety protections and age-appropriate study designs. Trials for children are particularly important because asthma medications approved for adults cannot always be assumed to work the same way in children. Pediatric allergists and pulmonologists at academic centers are the best source for finding these trials.