Phase 1 Cancer Clinical Trials
16 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–16 of 16 trials
Recruiting
Phase 1
A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations
CancerAdvanced Solid TumorsNSCLC (Non-small Cell Lung Cancer)+2 more
Alterome Therapeutics, Inc.188 enrolled9 locationsNCT06835569
Recruiting
Phase 1Phase 2
A Dose Finding Phase 1 of Sarilumab Plus Capecitabine in HER2/Neu-Negative Metastatic Breast Cancer and a Single-arm, Historically-controlled Phase 2 Study of Sarilumab Plus Capecitabine in Stage I-III Triple Negative Breast Cancer With High-Risk Residual Disease (EMPOWER)
BreastCancerMetastatic+2 more
University of Southern California65 enrolled3 locationsNCT04333706
Recruiting
Phase 1
A Study to Learn About Study Medicine ALTA2618 in Adults With AKT1 E17K-Mutant Solid Tumors
Breast CancerEndometrial CancerAdvanced Solid Tumor+2 more
Alterome Therapeutics, Inc.110 enrolled51 locationsNCT06533059
Recruiting
Phase 1
Positron Emission Tomography (PET) Imaging of Thrombosis
CancerAtrial FibrillationThrombosis+1 more
Massachusetts General Hospital165 enrolled1 locationNCT03830320
Recruiting
Phase 1
Phase I Study of SYS6043 in Patients With Advanced/Metastatic Solid Tumors
Breast CancerOvarian CancerCancer+4 more
Conjupro Biotherapeutics, Inc.386 enrolled1 locationNCT07424547
Recruiting
Phase 1Phase 2
Biomarker-Guided Allogeneic Single-Target or Dual-Target CAR-NK Cell Therapy for Advanced Solid Tumors
Breast CancerCancer
Essen Biotech85 enrolled1 locationNCT07410494
Recruiting
Phase 1Phase 2
EBNK-001 Allogeneic NK Cells With Low-Dose IL-15 ± Pembrolizumab in Advanced Solid Tumors
SarcomaCancerLeukaemia+2 more
Essen Biotech83 enrolled1 locationNCT07410676
Recruiting
Phase 1
TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers
Cancer
Tizona Therapeutics, Inc240 enrolled41 locationsNCT04485013
Recruiting
Phase 1
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
Breast CancerProstate CancerMetastatic Solid Tumor+3 more
Angiex, Inc.80 enrolled6 locationsNCT06440005
Recruiting
Phase 1
Safety/Efficacy Study of CID-078 in Patients With Advanced Solid Tumor Malignancies
Lung CancerAdvanced Solid TumorMetastatic Solid Tumor+2 more
Circle Pharma220 enrolled10 locationsNCT06577987
Recruiting
Phase 1
Phase 1 Trial of SYNC-T - Immunotherapy for Patients With Advanced/Metastatic Solid Tumors
Metastatic Breast CancerCancerMetastatic Cancer+2 more
Williams Cancer Foundation20 enrolled1 locationNCT05544240
Recruiting
Phase 1Phase 2
Phase I/II Clinical Study to Evaluate VB15010 Tablets in Patients With Advanced Solid Tumors
Breast CancerPancreatic CancerCancer+7 more
Zhejiang Yangli Pharmaceutical Technology Co., Ltd.188 enrolled1 locationNCT06819215
Recruiting
Phase 1Phase 2
A Study of OR502, a Monoclonal Antibody Targeting LILRB2, Alone and in Combination With Anticancer Agents
Advanced Solid TumorCancerNon-small Cell Lung Cancer+4 more
OncoResponse, Inc.168 enrolled4 locationsNCT06090266
Recruiting
Phase 1Phase 2
Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067
MelanomaCancerSolid Tumor+1 more
Simcha IL-18, Inc.316 enrolled6 locationsNCT04787042
Recruiting
Phase 1
A Phase 1 Study of CPO301 in Adult Patients With Advanced or Metastatic Solid Tumors
CancerCancer, Lung
Conjupro Biotherapeutics, Inc.102 enrolled13 locationsNCT05948865
Recruiting
Phase 1
Precision Therapy for Solid Tumors: Synergistic CDK4/6 Inhibition and Anti-VEGF Targeting LncRNA
CancerSolid Tumor
Lebanese University50 enrolled2 locationsNCT06307249