Phase 1 Metastatic Colorectal Cancer Clinical Trials
15 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–15 of 15 trials
Recruiting
Phase 1Phase 2
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Ovarian CancerEndometrial CancerMetastatic Cancer+6 more
Artios Pharma Ltd442 enrolled79 locationsNCT04657068
Recruiting
Phase 1
Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy
Metastatic Colorectal Cancer
M.D. Anderson Cancer Center27 enrolled1 locationNCT05985954
Recruiting
Phase 1Phase 2
Phase I/II Study of the Combination Immunotherapy Regimen: SX-682, TriAdeno Vaccine, Retifanlimab and IL-15 Agonist N-803 (STAR15) for Metastatic Colorectal Cancer (mCRC)
Metastatic Colorectal Cancer
National Cancer Institute (NCI)60 enrolled1 locationNCT06149481
Recruiting
Phase 1Phase 2
A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment BNT327 and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer
Metastatic Colorectal Cancer
BioNTech SE482 enrolled13 locationsNCT07079631
Recruiting
Phase 1Phase 2
A Multicenter Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic Colorectal Cancer Harboring KRAS G12C Mutations
Metastatic Colorectal CancerKRAS G12C Mutations
M.D. Anderson Cancer Center31 enrolled2 locationsNCT06412198
Recruiting
Phase 1
Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
Metastatic Breast CancerAdvanced Breast CancerMetastatic Lung Cancer+6 more
TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)392 enrolled31 locationsNCT06625775
Recruiting
Phase 1
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Metastatic Colorectal Cancer
Hoffmann-La Roche542 enrolled73 locationsNCT04929223
Recruiting
Phase 1Phase 2
5FU/LV, Irinotecan, Temozolomide and Bevacizumab for MGMT Silenced, Microsatellite Stable Metastatic Colorectal Cancer.
Metastatic Colorectal Cancer
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano27 enrolled3 locationsNCT04689347
Recruiting
Phase 1Phase 2
A FIH, Phase I/IIa, Trial Assessing Feasibility of Administrations of TIL-based Immunotherapy in Patients With Metastatic CRC and PC
Metastatic Colorectal CancerProstate Cancer MetastaticProstate Cancer Locally Advanced
Curacell Holding AB12 enrolled1 locationNCT07255664
Recruiting
Phase 1
Trial of ProAgio in Advanced/Metastatic Colorectal Cancer
Metastatic Colorectal CancerAdvanced Colorectal Cancer
University of Alabama at Birmingham27 enrolled1 locationNCT06867822
Recruiting
Phase 1Phase 2
Glumetinib Combined With Fruquintinib in the Treatment of MET Amplification or Protein Overexpression in Third-Line Unresectable Metastatic Colorectal Cancer
Metastatic Colorectal Cancer
Liu Huang42 enrolled1 locationNCT06980532
Recruiting
Phase 1Phase 2
A Study to Evaluate Safety and Efficacy of BEY1107 in Combination with Capecitabine in Patients with Metastatic Colorectal Cancer
Metastatic Colorectal Cancer
BeyondBio Inc.27 enrolled1 locationNCT05093907
Recruiting
Phase 1Phase 2
Sintilimab in Combination with Cetuximab and Chemotherapy As First-line Treatment for RAS/BRAF Wild-type Advanced Colorectal Cancer
Metastatic Colorectal Cancer
Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center30 enrolled1 locationNCT06776757
Recruiting
Phase 1Phase 2
Irinotecan, TAS-102 Plus Bevacizumab as a Second-Line Therapy in mCRC Patients
Metastatic Colorectal Cancer
Cancer Institute and Hospital, Chinese Academy of Medical Sciences70 enrolled1 locationNCT06202001
Recruiting
Phase 1
Dose Escalation and Expansion Clinical Trial of Irinotecan Liposome Combined With Oxaliplatin and 5-FU/LV Plus Bevacizumab as First-line Treatment of Metastatic Colorectal Cancer
Metastatic Colorectal Cancer
Shanghai Zhongshan Hospital78 enrolled1 locationNCT06225622