Phase 1 Alzheimer Disease Clinical Trials
29 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 29 trials
Recruiting
Phase 1
A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease
Alzheimer Disease
Eli Lilly and Company48 enrolled10 locationsNCT06297590
Recruiting
Phase 1
A Study of LY4006895 in Healthy Participants With Early Symptomatic Alzheimer's Disease (AD)
HealthyAlzheimer Disease
Eli Lilly and Company128 enrolled9 locationsNCT06657768
Recruiting
Phase 1
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
Alzheimer DiseaseMild Cognitive ImpairmentAlzheimer s Disease
University of California, San Diego60 enrolled1 locationNCT06548191
Recruiting
Phase 1Phase 2
Nicotinic Acid for the Treatment of Alzheimer's Disease
Alzheimer Disease
Indiana University30 enrolled1 locationNCT06582706
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL628 in Participants With Early Alzheimer's Disease
Alzheimer Disease, Early Onset
Denali Therapeutics Inc.68 enrolled1 locationNCT07328451
Recruiting
Phase 1
A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD
Early-Onset Alzheimer Disease
Alnylam Pharmaceuticals60 enrolled8 locationsNCT05231785
Recruiting
Phase 1
A Trial Evaluating the Effect of NIO752 on Tau Synthesis Measured by a Process Known as SILK
Alzheimer DiseaseAutosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 1 (Disorder)Autosomal Dominant Alzheimer Disease Due to Mutation of Presenilin 2 (Disorder)+1 more
University College, London10 enrolled2 locationsNCT06372821
Recruiting
Phase 1Phase 2
Deep Repetitive Transcranial Magnetic Stimulation (rTMS) of the Precuneus for Alzheimer Disease (AD)
Alzheimer DiseaseAlzheimer&Amp;Amp;#39;s DiseaseDementia Alzheimer Type+4 more
University of California, Los Angeles54 enrolled1 locationNCT06597942
Recruiting
Phase 1
Evaluation of the Safety, Tolerability, and Pharmacokinetics of J4 in Healthy Adults
Alzheimer Disease
Academia Sinica, Taiwan76 enrolled1 locationNCT06938763
Recruiting
Phase 1Phase 2
Study of ARO-MAPT-SC in Healthy Subjects and Subjects With Early Alzheimer's Disease
Alzheimer DiseaseAlzheimer Disease, Early Onset
Arrowhead Pharmaceuticals112 enrolled1 locationNCT07221344
Recruiting
Phase 1
UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy
Alzheimer Disease
University of Alabama at Birmingham160 enrolled1 locationNCT03809351
Recruiting
Phase 1
Door-Through-Door Companion Rideshare Technology for Individuals With Alzheimer's Disease and Related Dementias (AD/ADRD)
DementiaCognitive DeclineAlzheimer Disease or Associated Disorder
Onward Health, Inc120 enrolled1 locationNCT06850870
Recruiting
Phase 1
A Phase Ia/Ib, First-in-human (FIH) Study for Safety, Tolerability, Pharmacokinetics (PK), and Clinical Activity Evaluation of ADEL-Y01
Alzheimer Disease
Alzheimer's Disease Expert Lab (ADEL), Inc.73 enrolled6 locationsNCT06247345
Recruiting
Phase 1Phase 2
Clinical Study of SNK01 in Participants With Moderate Alzheimer's Disease
Moderate Alzheimer Disease
NKGen Biotech, Inc.36 enrolled5 locationsNCT06189963
Recruiting
Phase 1
Study to Evaluate the Relative Bioavailability of a New Formulation of NPT 2042 Soft-Gelatin Capsules Compared to the Original Formulation of NPT 2042
EpilepsyAlzheimer DiseaseEpilepsy Intractable
NeuroPro Therapeutics, Inc.8 enrolled1 locationNCT07222878
Recruiting
Phase 1Phase 2
Assess Fibrin in Brains With AD/ADRD
Alzheimer DiseaseDementia of Alzheimer Type
Massachusetts General Hospital30 enrolled1 locationNCT05336695
Recruiting
Phase 1
A Study to Assess THN391 in Subjects With Alzheimer's Disease
Alzheimer Disease, Early Onset
Therini Bio, Inc.15 enrolled4 locationsNCT06814730
Recruiting
Phase 1
Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease Participants
Alzheimer DiseaseMild Cognitive Impairment
Novartis Pharmaceuticals36 enrolled10 locationsNCT05469360
Recruiting
Phase 1
Study Safety and Efficacy of Deep Brain Stimulation (DBS) and Cervical Deep Lymphoid-venous Anastomosis (LVA) in Alzheimer's Disease
Alzheimer Disease
Chinese PLA General Hospital98 enrolled1 locationNCT07094438
Recruiting
Phase 1
R21 Roche: 3-Way Tau Tracers in AD
Alzheimer Disease
Washington University School of Medicine38 enrolled1 locationNCT05464368