Phase 1 Depression Clinical Trials
31 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 31 trials
Recruiting
Phase 1
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD)
Depression
National Institute of Mental Health (NIMH)64 enrolled1 locationNCT04582916
Recruiting
Phase 1
Open-Label Psilocybin Study in Transdiagnostic Population
AnxietyDepression - Major Depressive DisorderPTSD+5 more
Yale University50 enrolled1 locationNCT06442423
Recruiting
Phase 1
A Study to Explore the Effect of SP-624 on Brain Network Analytics in Healthy Adults and Adults With Major Depression
DepressionHealthyMajor Depressive Disorder
Sirtsei Pharmaceuticals, Inc.36 enrolled2 locationsNCT06570369
Recruiting
Phase 1
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
DepressionMajor Depressive DisorderMajor Depression
National Institute of Mental Health (NIMH)70 enrolled1 locationNCT03973268
Recruiting
Phase 1
Psilocybin for Treatment-Resistant Depression in Autism
Autism Spectrum DisorderTreatment Resistant Depression
Centre for Addiction and Mental Health20 enrolled1 locationNCT06731621
Recruiting
Phase 1
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
HealthyMajor Depressive DisorderTreatment Resistant Depression
Baylor College of Medicine100 enrolled2 locationsNCT06480201
Recruiting
Phase 1Phase 2
Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)
DepressionSequestra
First Affiliated Hospital of Chongqing Medical University520 enrolled1 locationNCT05814640
Recruiting
Phase 1
DBS for Depression
Treatment Resistant Depression
Northwell Health20 enrolled1 locationNCT06096207
Recruiting
Phase 1
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
DepressionHealthy VolunteerMajor Depressive Disorder
National Institute of Mental Health (NIMH)150 enrolled1 locationNCT03065335
Recruiting
Phase 1Phase 2
Personalized Ultrasonic Brain Stimulation for Depression (R61)
Depression - Major Depressive DisorderMajor Depressive EpisodeTreatment-Resistant Major Depressive Disorder
Brian Mickey30 enrolled1 locationNCT06902298
Recruiting
Phase 1
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
Depression
National Institute of Mental Health (NIMH)108 enrolled1 locationNCT05703685
Recruiting
Phase 1Phase 2
Enoxolone in Major Depression - Biomarker-outcome Relationship
Unipolar Depression
Philipps University Marburg80 enrolled1 locationNCT05570110
Recruiting
Phase 1Phase 2
Dapagliflozin in Depression
Depression
Tanta University60 enrolled1 locationNCT07239011
Recruiting
Phase 1
Pharmacologic Augmentation of TMS for Depression With D-serine
Depression
Mclean Hospital60 enrolled1 locationNCT06876129
Recruiting
Phase 1
Psilocybin in Chronic Low Back Pain and Depression
DepressionChronic Low-back Pain
Johns Hopkins University40 enrolled1 locationNCT06355414
Recruiting
Phase 1
Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use
Depression, AnxietyAnxietyDepression - Major Depressive Disorder+1 more
Trustees of Dartmouth College15 enrolled1 locationNCT06920238
Recruiting
Phase 1Phase 2
Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential in MDD Symptomatic Domains
Depression - Major Depressive Disorder
University of Cincinnati67 enrolled1 locationNCT06795451
Recruiting
Phase 1Phase 2
A Ketamine-assisted Group Therapy Intervention for Spanish-speaking Adults With Depression
Depression
Juliana Zambrano, MD, MPH10 enrolled1 locationNCT06597695
Recruiting
Phase 1
Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department
DepressionSuicideSuicidal Ideation
Lindsay Maguire, MD50 enrolled2 locationsNCT06085937
Recruiting
Phase 1
Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression
Treatment-resistant Bipolar Depression
The University of Texas Health Science Center, Houston30 enrolled1 locationNCT03522545