Phase 3 Depression Clinical Trials
28 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–20 of 28 trials
Recruiting
Phase 3
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
DepressionDepression - Major Depressive DisorderDepression in Adults+3 more
Cybin IRL Limited330 enrolled67 locationsNCT06793397
Recruiting
Phase 3
Low Frequency Right Dorsolateral Pre Frontal Cortical Repetitive TMS for Bipolar Depression
Bipolar Depression Depressed Phase
Tyler Kaster80 enrolled2 locationsNCT06986460
Recruiting
Phase 3
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
DepressionBipolar I Disorder
AbbVie380 enrolled78 locationsNCT04777357
Recruiting
Phase 3
Prefrontal Glutamatergic Modulation by NAC and MBCT for Depression in Youth
Mild Depression
University of Cincinnati160 enrolled1 locationNCT07464886
Recruiting
Phase 3
E-Mindfulness Approaches for Living After Breast Cancer
Breast CancerDepression
NRG Oncology402 enrolled277 locationsNCT06748222
Recruiting
Phase 3
Biomarker-guided rTMS for Treatment Resistant Depression
Major Depressive DisorderTreatment Resistant Depression
Weill Medical College of Cornell University348 enrolled2 locationsNCT04041479
Recruiting
Phase 3
PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study
Depression
Yale University400 enrolled6 locationsNCT06713616
Recruiting
Phase 3
A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
Bipolar DisorderBipolar I DisorderBipolar II Disorder+1 more
Xenon Pharmaceuticals Inc.400 enrolled26 locationsNCT07172516
Recruiting
Phase 3
Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure
Major Depressive DisorderBipolar DepressionSchizophrenia and Related Disorders
Dr. Inge Winter1,254 enrolled1 locationNCT05603104
Recruiting
Phase 3
Behavioral Activation Delivered Via Home-based Telehealth to Improve Functioning in Cardiovascular Disease Patients Recently Discharged From Inpatient Care
Cardiovascular DiseasesDepression
VA Office of Research and Development132 enrolled1 locationNCT04877197
Recruiting
Phase 2Phase 3
Resources, Inspiration, Support and Empowerment (RISE) for Black Pregnant Women
DepressionAnxietyInflammation+9 more
Cedars-Sinai Medical Center150 enrolled1 locationNCT05552053
Recruiting
Phase 2Phase 3
Combination Therapy for Treatment of Sleep Disturbance in Patients With Advanced Cancer
CancerDepressionSleep+2 more
M.D. Anderson Cancer Center188 enrolled1 locationNCT05474846
Recruiting
Phase 3
Improving Outcomes in Depression in Primary Care in a Low Resource Setting
DepressionDepressive Disorder
Harvard Medical School (HMS and HSDM)1,500 enrolled1 locationNCT05944926
Recruiting
Phase 3
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
Malignant Female Reproductive System NeoplasmAnxietySleep Disturbance+2 more
Wake Forest University Health Sciences160 enrolled2 locationsNCT05625360
Recruiting
Phase 2Phase 3
Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)
DepressionPost Traumatic Stress DisorderAnxiety Disorders
University of California, San Diego128 enrolled1 locationNCT06273527
Recruiting
Phase 3
The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Major Depressive DisorderTreatment Resistant Depression
Dr. Inge Winter418 enrolled12 locationsNCT05973851
Recruiting
Phase 3
The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Bipolar Depression
Dr. Inge Winter418 enrolled13 locationsNCT05973786
Recruiting
Phase 2Phase 3
Effect of Probiotics "Psychobiotics" on Depression and Metabolic Syndrome in Saudi Arabia
Depression Anxiety Disorder
Roaa Ahmed Alkreadees60 enrolled1 locationNCT06765057
Recruiting
Phase 3
Psilocybin-Assisted Therapy in Treatment-Resistant Depression
Treatment Resistant DepressionRefractory Depression
University of North Carolina, Chapel Hill23 enrolled1 locationNCT06303739
Recruiting
Phase 3
Ketamine Augmentation of ECT in Treatment-Resistant Depression
Major Depressive DisorderTreatment Resistant Depression
Università Vita-Salute San Raffaele30 enrolled1 locationNCT07088380